Comments on: The Role of CRH in Negative Health Effects of Stress

By: Shea

Shea — Mon, 09 Apr 2018 19:01:34 +0000

Birgit, if you go to this page and scroll further down the page, you can book with one of our consultants: https://selfhacked.com/contact/

By: Birgit R.

Birgit R. — Mon, 09 Apr 2018 12:10:35 +0000

This is so interesting Joseph M Cohen. Thank you! I was tested through selfdecode and it seems like I am the only person ever that has rs11657992 TT (this is homo, but none of my other CRH1 are mutated). So should I connect the following (se below) to this single, but super rare homo mutation?

I believe I have MCAS (a mast cell disorder) because I have multiple food intolerances, MCS and CFS.
I also have low blood pressure, very low SIgA and I guess leaky gut
I experienced a lot of anxiety when I was younger. I guess it is still there, I have just learned to cope. So all this seems to fit descriptions…?

But I have some difficulties understanding where to go from here?
Can I book a consultation with you?
Or could you give me a few clues here?
Like. does my CRH seems to be high (this is my understanding by now)? Should I try to lower it? How?

Regards Birgit R.

By: Sipora

Sipora — Sat, 10 Feb 2018 08:18:38 +0000

I’m confused. If I have chronic fatigue syndrome, you’re saying that romantic love will decrease the CRH? So it will make the fatigue worse? I am in a relationship now and feel that it has helped my fatigue levels. Because I am happy and in love.

By: whisperingsage

whisperingsage — Tue, 05 Dec 2017 23:11:29 +0000

Try a full spectrum whole food vitamin/mineral supplement, YEARS ago, when I lived in humid Santa Cruz, and fed our dogs generic dog food, (1970’s no meat based available then) we had bald dogs. We were told it was flea allergy. It may have been. Cortisone shots temporarily fixed it. I got Dr. Pitcairn’s Natural Pet book and started feeding raw meat and well cooked beans and brown rice plus vitamins to my dogs. They regrew their hair. You answer is in this blog, It keeps going back to real whole food. Full nutrition. Even though my mother went on the cheap for the dogs and they suffered, she made sure we got liver once a week. She knew the value of nutrients in liver. (I feed raw liver to my animals now). Joe has done A LOT of homework but we need to read up and not expect a shortcut. It is our life, we need to own it.
Other good insights on nutrition, Dead Doctors Don;t Lie , Joel Wallach, free videos on Youtube, and Dr. Mercola, and Weston Price who did a 9 year worldwide study all over the world when he noticed people’s health and development began to take a nosedive, the 1890’s was the Industrial Revolution and it packed a wallop on our health, across huge swaths of society. His study in Nutrition and Physical Degeneration is available free online.

By: An-Marie

An-Marie — Sun, 08 Oct 2017 18:54:40 +0000

Hi Andrea,
Maybe your son is allergic to soy ? And has his vitamin A level been checked ? And last, tried fish oil ?
An-Marie

By: John

John — Thu, 03 Aug 2017 15:41:13 +0000

I stumbled upon this while looking for solutions for someone who has Alopecia Areata. The dermatology solution is to just inject Cortisone into the scalp. I saw in this article that people who have this have less Cortisol. There must be a connection then in that the Cortisone causes the hair to regrow. Is there anything that can be done to help this condition? I also noticed that the person is usually tired. When the fall asleep you cannot wake them up easily, Maybe CRH connects to all this. Any possible enlightenment you could provide would be very appreciated

By: Nattha Wannissorn

Nattha Wannissorn — Sat, 04 Feb 2017 04:17:39 +0000

In reply to CM. Sometimes there are other causes, like inflammation and CRH/cortisol resistance.

By: CM

CM — Sat, 04 Feb 2017 03:03:11 +0000

Hi Joseph,
So I think a lot of us are wondering would reducing CRH be as simple as reducing stress?
Thanks!
Cara

By: AP

AP — Sat, 16 Jul 2016 17:26:57 +0000

Great article!

How would you suggest to lower CRH, besides taking benzos?

By: Charles

Charles — Sun, 20 Mar 2016 19:21:30 +0000

Have you heard of CRH-R antagonists? If you could block CRH release, you could, in theory, stop Mast Cell activation. Let me know your thoughts.

By: Sherry

Sherry — Fri, 11 Mar 2016 21:20:37 +0000

In reply to Robin.

Robin,

My twin sister, Bev was diagnosed with Mast Cell, we should talk. Just started taking T3 Cytomel along with a few others and the results have been phenomenal. Bev is one that can only try one thing at one time because of the mast cell, fibro, etc. etc. [email protected]. On a mission to tell the world with that complicated thyroid. Been over 13 yrs. suffering. Sherry

By: Joseph M. Cohen

Joseph M. Cohen — Wed, 02 Mar 2016 18:03:52 +0000

In reply to Jamie.

No money from this, which is my longest comment:

https://selfhacked.com/blog/living-more-skillfully-by-realizing-the-myth-of-human-rationality/#comment-13129

I don’t get significantly more for ICES than I do other products, but given that it’s more expensive, I make more money from it.

So some of the incentive for a longer response is monetary, sure. But I don’t give long response on anything now.

By: Jamie

Jamie — Wed, 02 Mar 2016 09:42:18 +0000

In reply to Joseph M. Cohen. Joseph, why are the only comments you offer meaningful replies to related to ICES? Is it because you get a lot of money from every ICES unit sold?

By: Joseph M. Cohen

Joseph M. Cohen — Sun, 14 Feb 2016 04:14:36 +0000

In reply to Andrea D'Rozario. I think it's just a coincidence and hydrogen water wasn't the cause

By: Andrea D'Rozario

Andrea D'Rozario — Sun, 14 Feb 2016 02:37:42 +0000

Hi Joseph,
My son has had eczema since he was 2 years old. It was only concentrated in a two small patches behind the knee. When I stopped giving him milk (Enfalac), his eczema disappeared. He used to get itchy every now and then if his sugar content increased, so I reduced that and he was well on his way until he turned 10 when it came back. He’s 12 now and just last year it started spreading upwards towards the thigh.
I put him on a hydrogenated water treatment (Izumio by Naturally Plus – orp of -700mV) and within 3 months, he had broken up in very itchy skin all over his body. It is at its worst on his ankles (dry, flaky and broken with scratching). Till today, I haven’t been able to rectify his intense itching. I have put him on a redox routine which has helped improve his skin condition but not the itching.
Reading your piece on CRH, makes me more curious as to how the hydrogenated water could have played a role in his system.

Any thoughts on this?

He hasn’t had any blood tests taken.
We live in Malaysia.
Thanks,
Andrea

By: AT

AT — Fri, 08 Jan 2016 00:35:26 +0000

Joseph,

Thanks for the enlightening details regarding CRH.

I’m in the process of getting my blood work done prior to booking a consult with you and I suspect I may also have a CRH problem.

Question is, how do you test for it? And if tests point to CRH how can one fix the underlying root cause? My primary prescribed an SSRI as part of whats going on with me (not helping so far) but in your post you indicate serotonin can increase CRH. Granted I’ve only recently begun an SSRI but if that feeds the CRH beast and it turns out I have a CRH problem how do you address the problem?

Look forward to consulting with you in the next few weeks.

By: Joseph M. Cohen

Joseph M. Cohen — Mon, 02 Nov 2015 23:03:19 +0000

In reply to Graeme.

http://www.ncbi.nlm.nih.gov/pubmed/22375940

By: Graeme

Graeme — Sun, 01 Nov 2015 20:18:17 +0000

What makes you think that methylation decreases CRH? Do you have a reference for this?

By: Drew

Drew — Sat, 31 Oct 2015 01:10:40 +0000

The question is: How does one normalize / reset their CRH? Is long term, daily meditation the answer?

By: Robin

Robin — Fri, 30 Oct 2015 01:43:54 +0000

Thanks for the heads up about the interview and the link to ices-questions. I will send it over soon. FYI…I keep alienating both my allopathic and integrative/functional medicine physicians with my desire for them to diagnose and prescribe medication or supplements according to the snp variation patterns that I believe are expressing. Sometimes they pay attention to CYP 450 data. Sometimes they are curious and they may dialogue a bit about the blend of genes and the snp points that I think could be contributing to my forms of dysregulation.. But ultimately, they indicate they were not trained to practice medicine in this fashion. It is lamentable that we live during a time that many who have the power to diagnose do not know the meaning of the word: to know something (nosis), through, thoroughly and entirely (dia). Thanks for helping this reader know something with a bit more depth and discrimination.

By: lordilol is dead(?)

lordilol is dead(?) — Fri, 30 Oct 2015 01:35:07 +0000

ah i should add that i had psoriasis 2 months ago, for a month and it went away.
either it was the stress , the viral infection to my throat(severe) which maybe wouldnt appear if i didnt have the stress.or the anitbiotics meant to treat this shit(should maybe use silver?), but got that under control.

By: lordilol is dead(?)

lordilol is dead(?) — Fri, 30 Oct 2015 01:30:45 +0000

oh no.
i was bullied at seventh grade to 9 th needles to say i felt like crap from 7-12 grade(social phobia?)
how much did my height fell off? what if went to a different school? how much would the damage go down otherwise?
fuck. why did i insist to keep going to that school?
lol. also the sentence about long lasting changes is worrying.
holyshit. i should just optimize my supplements to reduce stress and neuro inflammation.

By: Joseph M. Cohen

Joseph M. Cohen — Thu, 29 Oct 2015 23:17:08 +0000

In reply to Robin.

Thanks. You’re a good fit for a CRH problem.

I have an interview that I will release soon with a top mainstream (not into health) researcher from Stanford and he agreed that medicine should work more the way I approach it – from fundamental biology rather than symptoms.

If you have anxiety, you shouldn’t automatically be given an SSRI. The question should be is CRH causing your anxiety or is some other factor or both? And then you address the underlying cause. This approach requires problem solving, not strict formulas, as medicine currently works.

Functional medicine is also broken, btw. They talk about the root cause, but I haven’t heard a single person even mention CRH.

This is where you should ask your ICES Q: https://selfhacked.com/forum/index.php?threads/ices-questions.19/

By: Robin

Robin — Thu, 29 Oct 2015 20:46:12 +0000

Thank you for this post. As someone with systemic mast cell disease, Hashimotos disease and homozygous variations at CRHR1, your synthesis is illuminating. I wish clinical medicine had half of your zeal. Those of us with neuroinflammation seem to confound too many healers, which necessitates finding our own ways to mending/healing.

I’ve been trying to figure out, can ICES help with T4-T3 conversion (without over stimulating the extra mast cells….my mast cells degranulate with vibration)? If so, hypothetically, where might the best place be to place the coils (thyroid or liver) if you are on a T4 only medication? I’m trying to figure out how to further increase free T3 and reduce reverse T3.

Again, much gratitude. I’m hoping to be able to consult soon.