Any explanation on this at all ??

If not can you at least say “sorry guys no info on that as of yet” ??

Don’t get defensive man asking for “references” no one is saying you don’t know your stuff. Were just trying to understand it and we’re looking to you for help please.

Suffice to say I will say what Joseph won’t that YES there does seem to be a connection guys to SOD2 and copper/ zinc! Why ??? How do we know there’s a connection? Because we who are having this problem, which seems to me to be more than a few, we are living proof that a connection exists, otherwise we wouldn’t all be asking the same question and getting no answers.

Why or what is that connection nobody knows yet apparently?! But you are not crazy in thinking it!

Also, I do HBOT and its helped me. If you do it often, have your antioxidant levels checked.

I am curious about how having more 02 under pressure can effect ROS… do you have more bc you have more 02? If so you would think you would feel worse, not better.

Questions about supplementing… what do you think about SOD lozenges by Nutra West? Does that only make SOD1?

I need to get some serious answers about IRON. My doctor thinks I have subclinical iron deficiency because many of my symptoms are iron def symptoms (blue nails on hands and feet, fatigue, heavy menstruation.)

He says with my diet a manganese deficiency would be really rare. The research supports that manganese def. would be rare. Some sources say SOD2 will bind with iron when manganese is depleted, other’s say it can compete for binding in the mitochondria.

Any ideas about IRON and SOD2 would be SO appreciated!

And on SOD2, presuming I understand this right and this version is intracellular and works at mitochondrial level, does adenoB12 help the SOD2 enzyme? Same thinking on glutathione, as the acetyl-glutathione reportedly raises intra-cellular glutathione.

Also…SOD3 gene transfer in animals lowers insulin resistance, reduced obesity, increased adiponectin, lowered TNFa and IL6…

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/

It seems not. Thank you for pushing me to find the details.it seems that study only looked at SOD1, not SOD2, so we actually don’t know what happened with SOD2 – it very well have helped but they didn’t measure it.

However, this study shows that SOD2 was altered in a time dependent manner in Wistar rats with brain injuries.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547292/

From what I’ve learned at conferences for doctors, having the SNPs doesn’t necessarily mean a process doesn’t work at all – many times it’s just bottlenecked, making those of us with them having to work harder.

Anecdotally, I’ve done about 25 HBOT sessions, and while I felt a little woozy after the first 4 or so, I now am feeling that they’re benefiting me tremendously. (I also take manganese bisglycinate, and have been on a comprehensive antioxidant program including IV glutathione and vitamin C, before and during my HBOT treatments.)

Yeah but did those rats have SOD2 mutations?

Yes, that’s right.

I answered my own question. It will promote SOD production, a good thing.

http://www.sciencedirect.com/science/article/pii/S019701860300233X

Thanks

Thanks!

Vastly superior? Any company that uses stearate(s), not so superior — and that leaves me questioning the rest of their supply chain. If I can get a Thorne, Pure Encapsulations, Healthy Origins, Apex, etc, for about the same price, that’s vastly superior.

It decreases superoxide, not SOD

I have all of the SOD snp’s. I take SOD from seeking Health and it seems to help a bit but is not miraculous. I will try the maganese and MitoQ. Any other recommendations?
SOD2 rs2758331 AA +/+
SOD2 rs4880 GG +/+
SOD3 rs2855262 CC +/+

Correct

Because SOD supplements like GilSODin and Extramel (French Melon Extract) only produce SOD1 – not the mitochondrial MnSOD2 that is used in the mitochondria, which the SOD2 A16V SNP can cause lower levels of.

update Fred?

References?