Comments on: Factors that May Lower An Elevated Th17 Immune System

By: Hady

Hady — Sun, 03 May 2020 14:02:35 +0000

I have am a physician that has psoriasis.
Psoriasis is basically a disease of IL-17 and T17 cells.
Learning about the cytokine storm on sars cov 2 makes it point more toward the T17 cells being in overdrive which recruit more neutrophils and Reactive oxygen species leading to ards in the lung.
I am unmedicated and feel I made a mistake not placing myself on IL-17 blockers . They hypothetically sound like they can stop cytokine overdrive in this virus.

By: John R

John R — Wed, 23 Oct 2019 13:37:42 +0000

When you say “acts nonsynergistically with”, do you mean antagonizes?

By: Kelly

Kelly — Mon, 10 Jun 2019 21:30:05 +0000

Joe, you left out ME/CFS. High levels of TH17 have been found after exercise in a study by Nancy Klimas.

Also, if one gets enough niacin in the diet, or with supplements, then tryptophan won’t be broken down to make niacin, and thus won’t produce Kynurenic or worse, quinolinic acid.

By: Joe Cohen

Joe Cohen — Thu, 29 Nov 2018 15:49:13 +0000

In reply to Sebastian. The referenced study is about Tulsi, which is maybe 2% of UA

By: Diane

Diane — Tue, 13 Nov 2018 16:05:10 +0000

In reply to Ilko.

Hi- I am interested in the approach you suggest for RRMS.
Thanks,
Best,
[email protected]

By: Sebastian

Sebastian — Sun, 11 Nov 2018 00:13:39 +0000

Not sure Ursolic Acid should be on the list. It increses IFN-y:
https://www.ncbi.nlm.nih.gov/pubmed/21619917

By: Ilko

Ilko — Sat, 20 Oct 2018 15:27:06 +0000

In reply to Joseph M. Cohen. 100% !

By: Ilko

Ilko — Sat, 20 Oct 2018 15:25:35 +0000

In reply to Dani.

Dani

Contact me if you want to have a quick rundown or rather the top 10 things, some of which pleasurable, in order to stop your MS progression .. Someone very close to me developed it years ago and stopped its progression years back (!) , partially with my help.

I hope you’ll see my gmail

Regards,
Ilko

By: Jamie

Jamie — Sun, 08 Jul 2018 11:55:47 +0000

And this is why anybody with alopecia areata or barbae should stear well clear or l arginine or l citrulline. I remember watching a video on youtube of how a guy developed alopecia barbae after taking a male multivitamin, my guess is that multivitamin was Wellmans vitobiotics with it having arginine in the listed ingredients.

By: Jamie

Jamie — Sun, 08 Jul 2018 11:53:18 +0000

And this is why anybody with alopecia areata or barbae should stear well clear or l arginine or l citrulline. I remember watching a video on youtube of how a gut developed alopecia barbae after taking a male multivitamin, my guess is that multivitamin was Wellmans vitobiotics.

By: Sarah

Sarah — Thu, 28 Jun 2018 23:53:07 +0000

Hi Joe,
I had glandular fever when I was 12 and was in bed for two months. As a teenager I was very hirsute and had male pubic pattern and a few chest hairs and chin hairs. I also had a strong libido. I found out I had PCOS when I was 18. The endocrinologist suggested Spironolactone to decrease hits u it is my but I didn’t stay with it. In my 30s I was training hard in physical theatre but noticed a cyclic malaise and fatigue. I wondered if I had Ross River or Lyme’s disease as I had moved to northern Australia where I got tick bites and mosquito bites but never tested for it. When I was 38 I had my son delivered by cesarean and I felt awful especially three months after the birth where I became adrenally fatigued couldn’t metabolise glucose, put on heaps of weight and saw my teeth decay. I worked out that all the msg in Japanese foods was contributing to my I’ll health and cut out wheat dairy and high sugar or processed foods. I stabilised my weight when I came back to Australia following gluten free dairy free diet, but still had cyclic malaise. Around mid forties I started getting Peri menopausal symptoms and now at 53 my menopause symptoms are increasing but I also have fibroids, my hair is thinning, and greying, joint inflammation, sluggish metabolism, periods every 21 days, low iron, very sore breasts five days in from my new cycle and bad pms and weight gain. I know I’m getting older and my menopause is exacerbating my underlying conditions but I can’t seem to find a doctor open minded enough to look at this picture and acknowledge the role of Epstein Barr and it’s targeting my genetic predisposition. What do you think I should do? How do I find out if I’m Th1 or 2? Even though I have weight issues I seem to have Th1 symptoms rather than allergic responses.

By: Melissa Stutler

Melissa Stutler — Sun, 25 Mar 2018 03:14:55 +0000

You can add PANS/PANDAS to your list of diseases. https://www.jci.org/articles/view/80792

By: Patricia

Patricia — Thu, 23 Nov 2017 21:07:29 +0000

So supplementation 5htp. It is bad for this case ????? Thanks is advance .

By: John

John — Mon, 21 Aug 2017 16:11:58 +0000

Promote means you should do it/take it, it’s good for reducing TH17

By: Ella

Ella — Thu, 22 Jun 2017 05:02:45 +0000

I have vitiligo and alopecia plus u have been taking metdormin for over 10 years. Does this mean i can gave an elevated th17. What can i do to lower it.

By: Nick Stojanovich

Nick Stojanovich — Fri, 16 Jun 2017 19:17:19 +0000

Lifestyle to inhibit Th17
Avoid stress I understand this also I understand avoiding strenuous excercise
Why no Sun or nitric oxide

By: Dani

Dani — Fri, 28 Apr 2017 16:36:07 +0000

I have psoriasis and multiple sclerosis. My best goals are: Not to eat gluten and to respect circadian cycles strictly 7 days a week.

I find the information in this article very useful. Thank you very much!

By: Alaina

Alaina — Mon, 17 Apr 2017 17:50:29 +0000

In reply to Kimberly Lohr. I was rather confused as well. Thanks for asking this question! The author should have specifically stated the definition, instead of ambiguity in parentheses.

By: surfinthetao

surfinthetao — Sun, 09 Apr 2017 02:10:17 +0000

Joe, thanks for your site. If you ever want to do a piece on interstitial cystitis, contact me, maybe we can put some interesting pieces together for some people. I also have an idea for an IC supplement.

I am a sufferer of interstitial cystitis, and histamine seems to be related to (IC). I noticed I do well on these supplements listed in this article, as well as many of the IL-6 inhibitors you mentioned on your site, which this study links to bladder problems.

HB-EGF, and APF could be other factors for investigation that the study below talks about.

New theories in interstitial cystitis
Nature Clinical Practice Urology (2004) 1, 85-89
doi:10.1038/ncpuro0057
Received 3 August 2004 | Accepted 2 November 2004

Carnosine seems to help, which could be partly due to reduction of crosslinking of collagen from AGE’s? and somehow related to RAGE, the receptor for advanced glycation endproducts, and the bladder’s protective glycosaminoglycan (GAG) layer? type 1 and 3 collagen seemed to help for awhile, but then i broke out, although type 2 seemed help a bit with no symtoms.

A lot of information from a lot of experimentation maybe you could put together.

-J

By: LP

LP — Thu, 09 Mar 2017 12:55:48 +0000

I’m very interested reading this. I suffer from psoriasis, and it seems very promising new treatments work by inhibit IL-17. If taking ursolic acid also inhibits IL-17… has anyone tried this for psoriasis? Would it work?

By: Nattha Wannissorn

Nattha Wannissorn — Sun, 26 Feb 2017 20:49:04 +0000

In reply to Kimberly Lohr. The (Promote) means you should take it.

By: Kimberly Lohr

Kimberly Lohr — Sun, 26 Feb 2017 19:19:29 +0000

you say what can inhibit but then says )promote). But those are opposite actions … I’m confused but want to help myself since I have autoimmune disease.

By: drbiagiandrea

drbiagiandrea — Thu, 22 Dec 2016 14:49:06 +0000

Hi
i have a question about exercise and autoimmune disease:
if to lower Th1 i have to do high intensity exercise(yuo write in article about Th1) why to lower Th17 i have not to do high intensity exercise since some autoimmune disease have both Th1 Th17 culprit

By: Guy

Guy — Fri, 18 Nov 2016 20:45:59 +0000

In reply to Mikey. What is TULIP Protocol.?