Comments on: Glucocorticoid Receptors: Control Your Levels of Stress

By: Felix

Felix — Sat, 28 Sep 2019 16:25:44 +0000

The “HPA axis” is always so damn baffling whenever it is mentioned anwhere. I think you should give this thing its own article. One can never find any real mechanistic explanation, or why it is always spoken of as a “unit”, when otherwise parts are often talked about independently.

By: Daniel

Daniel — Tue, 23 Jul 2019 16:42:31 +0000

How does one repair the glucocorticoid receptors if they are damaged from chronic stress? Also, do you know where one can get the GR challenge test done at or is it just for laboratory testing in animals?

By: Jeffrey Florentino

Jeffrey Florentino — Wed, 05 Jun 2019 01:35:30 +0000

In reply to Cathi.

Thanks for your comment. To get answers to your health questions, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Cathi

Cathi — Sun, 02 Jun 2019 05:06:36 +0000

How does one attenuate or reduce an exaggerated or hyperactive negative glucocorticoid feedback response (or dexamethasone hypersuppression, as it is referred to in the literature). This problem is a hallmark of those suffering from PTSD, but can also be induced by a viral or chemical insult, and others have a genetic predisposition for this. Do you know of any drug, activity, of nutrient that will reverse or reduce this overactive negative feedback loop, the result of which is very low cortisol.

By: Edith

Edith — Sun, 20 May 2018 19:22:43 +0000

So what could I do when I have NR3C1 aa meaning an insensitivity of the glucocorticoid receptor? How could I interfere and stimulate its resistancy?

By: Kaila Setlak

Kaila Setlak — Sun, 04 Feb 2018 13:49:08 +0000

It’s arduous to find knowledgeable folks on this matter, but you sound like you know what you’re talking about! Thanks

By: Leizel

Leizel — Fri, 20 Oct 2017 05:39:49 +0000

Hi Bernadette, I see that you had a question about hydrocortisone a few months back. I’m interested in finding out if you had figured anything out since then about this issue. I am in the same boat, with use of potent corticosteroids to help with my severe case of eczema. Your response would be greatly appreciated!

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Tue, 25 Jul 2017 15:13:44 +0000

In reply to bernadette Fritz.

Joe doesn’t personally reply to health questions. You can book a consult with him at selfhacked.com/contact or join VIP at https://selfhacked.lpages.co/selfhackedvip/

By: bernadette Fritz

bernadette Fritz — Mon, 24 Jul 2017 11:35:00 +0000

Joe: On very low dose hydrocortisone and want deperately to get off. On not more than 10 mg. But I think my adrenals are a bit run down from detoxing and allergies related to hashimotos’s. Any suggestions? I really don’t want to go to a doctor, but maybe I should?? Almost 2 yrs on it. thank you

By: Noel Quinn

Noel Quinn — Sun, 23 Jul 2017 18:25:13 +0000

Are there any supplements that will support/enhance healthy receptors?

By: Dorothy Baker

Dorothy Baker — Sun, 23 Jul 2017 17:39:46 +0000

Wow, this info is technical. I guess it’s helpful for people who can take supplements to know what not to take, but other than experimental drugs which aren’t available & no doubt have side effects, can anything effective be done? That’s the bottom line. It takes time, energy, & brain functioning to read & understand all this info. Is there a real solution with an effective track record–that’s all we really need to know–is there a way to turn off the mutations? After extensive research & experimentation, the only thing that seems to work for me is eat the few foods I tolerate & forget synthetic vitamins & the natural ones, too–I don’t tolerate any of them. My diet feels unsustainable & deficient, but the alternative is even worse–the symptoms make life unbearable. A combination of challenging genetics, pesticide poisoning, & a “better living through chemistry” world.

By: Kim

Kim — Tue, 18 Jul 2017 23:30:37 +0000

Great to know two things I take as supplements I shouldn’t be taking.. especially with my Adrenal Fatigue. And I’ve been saying B6 makes me feel like crap. Now I know why!