Comments on: 5-HT2C Receptors: What Are They, And What Do They Do?

By: lalanifaiyaz@gmail.com lalanifaiyaz@gmail.com

lalanifaiyaz@gmail.com lalanifaiyaz@gmail.com — Fri, 08 Jan 2021 22:20:40 +0000

Absolutely. There are also several other overlapping pathways, in addition to the 5HT-2c receptorome, that would be perturbed and relate to the mimicked symptoms.

By: Jill

Jill — Tue, 04 Aug 2020 21:03:27 +0000

I read your informative article and have a question: Once someone has been addicted to narcotics, could hormonal problems such as hypothyroidism and menopause mimic opioid withdrawal with decreased dosing of HRT or hypothyroidism meds since they all have 5-HT2c receptors involvement? Thanks

By: Felix

Felix — Sun, 11 Nov 2018 14:42:25 +0000

I don’t think Fish Oil does really downregulate the receptor. If so, it would mirror Kudzu (which is effective) and indeed be a kind of miracle-supplement in a new way (e.g. for libido). However the opposite is the case, as I have verified myself several times over.

It is as such similar to Bacopa…

(I could mention as sort-of “credentials” that I’ve seen various other results linked here, even if from genuine studies, contraindicated in other, more recent studies.)

I also find it worth mentioning that the layout with the HUGE, in-your-face letters is terrible for reading, especially on mobile/tablet (mostly because one can’t adjust the size, it’s terrible either way).

By: Salma

Salma — Mon, 20 Nov 2017 09:39:12 +0000

Excellent

By: farshad

farshad — Sat, 23 Sep 2017 12:47:25 +0000

cant progesterone also block 5ht2c?

By: Marie

Marie — Wed, 13 Sep 2017 17:36:03 +0000

What is a save brand for kudzu root ? Has someone experiences from trying it ?

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Fri, 11 Aug 2017 15:00:25 +0000

In reply to Mr. Sick.

You are right it is confusing. (I didn’t check the full-text to respond to this comment.)

What can happen is that it can increase mRNA expression but also bind and block the receptors (regardless of numbers of receptors) at the same time.

Generally increasing mRNA should increase the receptor production but it’s not always the case.

So to say that the substance has antagonistic effects could mean that it increases the number of receptors but also reduce the activity of the receptors.

By: Mr. Sick

Mr. Sick — Fri, 11 Aug 2017 12:22:18 +0000

The question is the one I posted before. I always thought upregulating the mRNA means increasing the receptor. So that his would have an agonistic effect. But according to that study, it’s the other way around. It is saying, that mangosteen upregulates the receptor and this is supposed to be antagonistic.

Here is my post again:
On your 5ht2a article, you cite this study as proof, that mangosteen is a 5ht2a antagonist:
https://www.ncbi.nlm.nih.gov/pubmed/21440614

Accordingly, mangosteen should be a 5ht2c antagonist as well. What I find startling is, that the study is concluding:
“The ability of γ-mangostin to enhance the expression of 5-HT(2A/2C), muscarinic, histamine and bradykinin receptor mRNA suggests that this compound has antagonistic effects”

I dont understand that. Increasing mRNA expression sounds like an upregulation to me. The receptor is fortified, isn’t it?

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Fri, 11 Aug 2017 02:16:38 +0000

In reply to Mr. Sick. We just don't use the term because it throws off a lot of readers. We are trying to minimize the number of Chrome tabs people need to understand our posts. Now, where do you see the problem or something incorrect?

By: Mr. Sick

Mr. Sick — Thu, 10 Aug 2017 17:28:28 +0000

So seems like you people don’t know either, what mRNA expression does, too bad.

By: Mr. Sick

Mr. Sick — Mon, 31 Jul 2017 16:47:15 +0000

I’d love to hear the take of nattha or joe on Mangosteen being a potential antagonist of 5ht2c.
On your 5ht2a article, you cite this study as proof, that mangosteen is a 5ht2a antagonist:
https://www.ncbi.nlm.nih.gov/pubmed/21440614

I dont understand that. Increasing mRNA expression sounds like an upregulation to me. The receptor is fortified, isn’t it?
I would appreciate an explanation.

By: Mr. Sick

Mr. Sick — Thu, 20 Jul 2017 17:28:46 +0000

All those statements get along with each other. Maybe you are mistaking catecholamines with corticoids?
catecholamines are Serotonin, dopamine, noradrenaline, adrenaline. And at least Serotonin is increased with SRRI

By: Karen

Karen — Thu, 30 Mar 2017 20:12:35 +0000

In reply to Maddy.

I have also been very confused by 5HT2C CRH stimulation question. I have read the following:
‘5-HT(2C)R activation is necessary for 5-HT-induced HPA axis activation.’
‘Fluoxetine is a competitive and reversible antagonist of 5HT2C receptors’
‘Fluoxetine induces a significant increase in catecholamines’

The only way all three of these statements can be true is if antagonizing a receptor is the same thing as activating it. But that just sounds wrong. I would love to have this question cleared up.

By: Maddy

Maddy — Tue, 24 Jan 2017 18:56:48 +0000

OK, confused. the 5HTC2 receptor, I have read what you posted that it significantly increases CRH, and I think this is why some people do NOT get the sleepy/sedated feeling from an SSRI, but rather get keyed up. Because CRH begets ACTH and invokes adrenals and all of the ouputs there…cortisol, dhea, adrenaline, noradrenaline. So cortisol is very well known for INCREASING insulin, and insulin increases appetite and generally causes weight gain, which I thought was one of the chief ways SSRI’s induce weight gain. But you also say that 5HTC2 reduce appetite and weight gain? How can increasing cortisol be congruent with that?
I have a child with what I think is a slow MAO-A, yielding higher levels of serotonin and adrenaline, who has anxiety issues. Prescribed an SSRI, and wow not good. More serotonin was not good. Any tips on REDUCING CRH?

By: Joseph M. Cohen

Joseph M. Cohen — Sun, 26 Jul 2015 20:41:47 +0000

In reply to om. Try it out and if it works for you get back to me.

By: om

om — Sun, 26 Jul 2015 19:26:51 +0000

Slightly off topic but What you think about beyond tangy tangerine 2.0 for supplementation? worthy investment?
https://www.youtube.com/watch?v=Xhtc1S5Yl8o

By: Joseph M. Cohen

Joseph M. Cohen — Sun, 26 Jul 2015 13:52:12 +0000

In reply to Ole. yes, interesting...

By: Ole

Ole — Sun, 26 Jul 2015 10:47:43 +0000

Not quite sure if this relates, but i have 3-4 years of experimenting with tweaking my hormones. When i make estrogen/E2 hit rock bottom (with letrozole) i have a constant state of panic and a feeling of peeing myself (its some weird warm sensation in my legs and pelvic area that is probably just the body heat sensation being misinterpreted by the brain? Ive heard panic attacks are mostly a misinterpretation by the nervous system of bodily sensations.)

I have panic disorder without having rock bottom estrogen, but with low estrogen i get all the physical effects. Dilated pupils, rapid heartrate, insane sweating to the point of soaking clothes, constant need to visit the bathroom, no appetite etc.

Might be useful for you to know. Could be of relevance to this subject?